MOTS-c vs Humanin
Both are mitochondrial-derived peptides, encoded in different regions of mitochondrial DNA.
Last reviewed and updated:
How do they compare?
| Feature | MOTS-c | Humanin |
|---|---|---|
| Molecule type | Mitochondrial-derived peptide | Mitochondrial-derived peptide |
| Encoding gene | Mitochondrial 12S rRNA region | Mitochondrial 16S rRNA region |
| Length | 16 amino acids | About 21 to 24 amino acids depending on form |
| Research focus | Metabolic signaling, AMPK-associated pathways, stress response | Cytoprotection, metabolic signaling |
| Evidence base | Mainly cell and mouse studies; limited human measurements | Mainly cell and animal studies |
Interpretation
This is a research comparison, not a recommendation. See the glossary for terms.